Eli Lilly is testing a way to prevent covid-19 that’s not a vaccine

Climate change-fueled heatwaves could kill millions 

Sponsored by Insight The Download Your daily dose of what’s up in emerging technology 08.04.20 Good morning! Today: an antibody drug being trialed by Eli Lilly could help tide us over until a covid-19 vaccine, and climate change-fueled heatwaves could kill millions. Get your friends to sign up here to get The Download every day. Eli Lilly is testing a way to prevent covid-19 that’s not a vaccine Nurses and patients in some US assisted living facilities will receive an antibody drug to prevent covid-19 infection. The drug: Early in the pandemic, companies searched the blood of covid-19 survivors for potent antibodies against the novel virus. This drug, manufactured by Eli Lilly, is one of these Y shaped proteins—it’s a natural antibody manufactured at a larger scale. The trial: To carry out the study, which will involve 2,400 people, Lilly will target nursing homes with covid-19 outbreaks. In some areas, elderly residents in nursing homes account for the majority of covid-19 deaths. How it works: Just like natural antibodies, Lilly’s antibody should grab onto the virus and block it. Similar antibody treatments proved effective in treating Ebola disease, but the goal here is to prevent infection by giving the drugs earlier. Prevention with antibodies is known to work. However, while vaccines confer “active immunity”—your body learns to make its own antibodies against a germ—adding antibodies artificially only offers “passive” immunity. This only lasts as long as the antibodies can stay in the bloodstream, so weeks or months.  Plan B: Antibody treatments could reach the market before a vaccine. It could be a big deal for protecting health care workers and the most vulnerable. Read the full story. —Antonio Regalado Climate change-fueled heatwaves could kill millions Blistering heatwaves are breaking temperature records around the globe this year. And it’s only going to get worse, as climate change accelerates. By the end of this century, extreme heat spells could kill roughly as many people as all infectious diseases combined, including HIV, malaria and yellow fever, according to a new study. The findings: Heatwaves will kill an additional 73 people per 100,000 by 2100, under a scenario in which nations continue to pump out high levels of greenhouse gas emissions, according to research by the Climate Impact Lab, a group of climate economists and researchers at several US universities. In some of the hottest and poorest parts of the world, the mortality rate could reach or exceed 200 deaths per 100,000. But … A growing number of climate researchers argue such a high-end scenario is too pessimistic given flattening global emissions. Under a more optimistic scenario in which greenhouse gas pollution peaks around 2040 and begins falling thereafter, additional deaths would decline to 11 per 100,000. But depending on the population at that point, that could still be around a million extra fatalities. Read the full story. —James Temple We can still have nice things A place for comfort, fun and distraction in these weird times. (Got any ideas? Drop me a line or tweet 'em at me.)   + An ode to America’s “best” wedding band.   + What Lego can teach us about physical interface design.   + One for the Brits...there’s a theory circulating online that Nando’s Medium Peri Peri Sauce is actually hotter than Nando’s Hot Peri Peri Sauce. 😮   + Today’s new word? “Betwattled”: a 17th-century term meaning “confused, bewildered, or out of one’s senses.” Or, as I call it, “Tuesday.”   + Tis the season to make slaw.   + Fyre Festival branded clothing is up for auction.   + This poundcake recipe is so easy, even I might be able to make it.   + Meowflix. It’s Netflix, but for cats.   + Stuck in the city this summer? Here’s how to make the most of a staycation.   + The Journal of Interdisciplinary History is celebrating its 50-year anniversary with 11 special, free articles. Sponsor Message 2020 Insight Intelligent Technology Pulse: The impact of covid-19 on business readiness Insight surveyed 200 IT professionals to find out how prepared they were to take on the covid-19 impacts on budgets, priorities, and new responsibilities. In a series of multiple-choice and open-ended questions, Insight gathered a candid view of the state of enterprise IT. This special edition of the Insight Intelligent Technology Index™ was created to help IT professionals and their organizations understand the immediate and lingering impact of the covid-19 pandemic on enterprise IT. You’ll learn how organizations and IT teams adapted to the impacts of the global pandemic to support business continuity—and how strategic plans have been changed. Get the report. The top ten must-reads I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology. 1 What went wrong with the US response to covid-19 The current situation was predictable and preventable at every turn. (The Atlantic)   + Fauci defended Birx’s comments that the US has entered a “new phase” of uncontrolled spread. (NYT $)   + Spain’s young and middle aged are the main victims of a new wave of infections. (AP)   + While the virus kills more men, women still bear a heavy burden. (Undark) 2 Coronavirus deaths in Iran are nearly triple what its government claims It is the worst-hit country in the Middle East. (BBC) 3 The TikTok deal would make it harder to tackle Big Tech Trump is using the threat of a ban to help a giant US tech company become even bigger. (Recode)   + Trump says the US government should get a portion of any sale price. (WSJ $)   + There’s a lot that needs to be ironed out. (Wired UK)   + This isn’t the first time Trump has tried to dictate corporate decisions. (NYT $) 4 A quantum version of the game Go would be much harder for AI to beat Try your hand at THAT, AlphaZero. (New Scientist $) 5 US scientists worry about politics influencing vaccine development 💉 There’s a good reason they take so long to develop: we need to prove they are safe. (NYT $) 6 Twitter expects to be fined up to $250 million for its hack  Companies pay a high price these days for lax security. (CNBC)   + A high-profile Black UK politician says Twitter is not acting quickly enough over racist threats. (BBC) 7 How New York City’s young essential workers are coping with the pandemic Many of them are being forced to grow up very quickly. (New Yorker $) 8 Garmin reportedly paid a multi-million dollar ransom to cyber criminals And that’s why ransomware attacks go on and on. (Sky) 9 Fatigued by TV? You’re not alone 📺🥱 Try gaming, I guess? (The Verge)   + PS4 game sales almost doubled during the pandemic. (Engadget) 10 House hunting is going virtual 🏡🔍 Software designed for gaming lets people visit prospective homes without leaving their existing one. (BBC) Get the story behind the story. Check out Deep Tech, a subscriber-only podcast from MIT Technology Review. Go deeper on our best stories and ideas. Listen here. Quote of the Day “America wants to kick us out, while China doesn't allow us to return.” —Shizheng Tie, a senior student at John Hopkins University, tells the BBC that Chinese students in the US feel increasingly unwelcome yet also face hostility on Chinese social media. Top image credit: Eli Lilly Please send Nando’s Medium Peri Peri Sauce to hi@technologyreview.com. Follow me on Twitter at @charlottejee. Thanks for reading! —Charlotte Was this newsletter forwarded to you, and you'd like to see more? Sign up for free Leading with Innovation. Join us online, October 19-22. *View this in a browser You received this newsletter because you subscribed with your email address  *Edit email preferences   |   *Unsubscribe from all emails Follow us: MIT Technology Review One Main Street Cambridge, MA 02142

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